. 2014 Jun;28(6):2538–2550. doi: 10.1096/fj.13-247221

Table 1.

Differential hyperoxic lung injury phenotypes in neonates from 36 strains of inbred mice

Strain	Parameter	Protein (μg/ml)		Total cells		Neutrophils (%)		Macrophages		Epithelial cells
Strain	Parameter	Air	O₂	Air	O₂	Air	O₂	Air	O₂	Air	O₂
129 × 1/SvJ	Mean	70.7	98.6^*	33,333	35,833	0.08	2.48^*	21,894	24,362	5,578	4,557^*
	sem	10.6	9.9	4,278	4,345	0.08	0.28	2,547	1,681	1,568	423
	n	6	9	6	9	4	7	4	7	4	7
129S1/SvImJ	Mean	71.8	109.3	36,806	53,194^#	0.19	2.72^*	27,608	40,730^#	5,367	7,523^#
	sem	9.7	10.4	4,654	4,349	0.12	0.44	3,749	4,645	795	1,054
	n	9	18	9	18	7	13	7	13	7	13
A/J	Mean	46.4	95.6^*	17,500	30,769	1.18	3.11^*	13,978	34,097	2,395	11,001^#
	sem	2.7	12.3	1,887	5,134	0.64	0.77	1,446	3,409	446	2,467
	n	9	14	9	13	4	6	4	6	4	6
AKR/J	Mean	60.2	89.4^*	20,673	24,688	5.44	5.38^*	14,621	19,674	2,703	5,651^*
	sem	4.4	6.8	1,881	1,405	0.73	0.82	1,588	1,504	468	756
	n	13	16	13	16	3	7	3	7	3	7
BALB/cBy	Mean	35.2	64.3^*	24,063	24,853	1.46	5.11^*	21,766	2,4932	3,282	3,994^*
	sem	8.0	5.4	1,866	1,991	0.59	1.74	1,073	2,592	146	1,026
	n	4	17	4	17	5	6	5	6	5	6
BALB/cJ	Mean	28.4	80.6^*	39,375	39,643	0.47	4.62^*	33,061	43,929^#	6,292	7,167
	sem	1.7	6.3	3,576	1,864	0.08	0.67	4,076	4,913	843	774
	n	6	8	6	7	5	7	5	7	5	7
BTBR T+tf/J	Mean	76.2	111.1	31,750	28,456	0.00	0.41^*	24,981	16,904^*	7,019	7,334^#
	sem	8.3	9.0	5,327	3,350	0.00	0.16	6,753	4,676	1,184	1,447
	n	13	16	10	17	5	9	5	9	5	9
BUB/BnJ	Mean	54.6	98.0^*	10,313	26,111	0.17	3.54^*	7,398	19,767	2,893	3,769^*
	sem	8.4	6.4	1,288	2,119	0.09	0.67	1,053	2,531	485	667
	n	8	8	8	9	9	8	8	8	8	8
C3H/HeJ	Mean	43.1	249.1^#	12,692	37,938	1.74	13.30^#	11,185	23,870	2,257	5,802
	sem	8.0	16.5	1,216	4,227	0.33	1.02	1,670	3,047	373	570
	n	13	25	13	20	9	18	9	18	9	18
C57BL/10J	Mean	46.2	79.6^*	62,292	61,136^#	1.56	8.24	53,483	42,492^#	6,635	13,647^#
	sem	6.1	10.0	6,385	3,897	0.53	1.21	5,875	3,540	981	1,389
	n	6	11	6	11	6	11	6	11	6	11
C57BL/6J	Mean	48.3	135.9	23,875	43,355	1.10	8.60	19,138	31,573	4,464	7,381^#
	sem	7.4	14.1	843	4,626	0.40	1.12	679	4,449	772	913
	n	12	19	10	19	10	19	10	19	10	19
C57BR/cdJ	Mean	72.8	92.1^*	15,583	16,250^*	0.53	5.07^*	11,551	10,305^*	4,940	3,769^*
	sem	7.5	8.6	1,156	1,021	0.17	0.63	1,113	916	676	373
	n	13	22	15	22	10	15	10	15	10	15
C57L/J	Mean	46.3	183.9^#	14,896	27,679	0.13	7.50	11,342	21,072	3,317	5,381^*
	sem	9.3	25.1	1,527	1,925	0.06	3.29	2,044	2,581	521	884
	n	12	14	12	14	7	8	7	8	7	8
C58/J	Mean	63.4	154.3	34,554	34,803	1.56	11.44	24,859	25,410	9,191	7,765^#
	sem	3.8	10.5	4,599	3,031	0.57	1.42	6,688	2,558	1,470	766
	n	14	19	14	19	8	14	8	14	8	14
CAST/EiJ	Mean	85.1	104.3^*	11,000	11,458^*	4.80	8.52	7,584	7,064^*	2,680	3,154^*
	sem	17.1	26.4	1,000	1,528	1.78	3.05	1,068	1,049	286	736
	n	7	6	5	6	4	5	4	5	4	5
CBA/J	Mean	36.3	102.1^*	23,000	26,375	0.09	9.88	17,851	23,320	2,663	4,373^*
	sem	4.6	13.2	2,682	2,792	0.09	1.98	2,374	2,540	199	837
	n	10	9	10	10	7	5	7	5	7	5
CE/J	Mean	82.0	157.5	17,404	24,438	0.34	5.76	6,424	14,326^*	2,271	5,265^*
	sem	5.1	7.3	2,353	1,588	0.21	0.56	730	1,625	218	394
	n	12	19	13	20	5	11	5	11	5	11
DBA/2J	Mean	68.3	181.1^#	18,750	25,703	1.00	5.42	14,412	18,159	3,920	4,531^*
	sem	10.6	22.9	1,518	2,848	0.38	0.95	1,800	2,400	451	497
	n	16	17	16	16	10	12	10	12	10	12
FVB/NJ	Mean	101.2	202.1^#	15,000	37,981	2.38	8.71	13,037	29,737	3,225	7,271
	sem	16.3	19.3	1,869	3,332	1.19	1.12	2,533	2,863	517	1,344
	n	11	13	11	13	7	11	7	11	7	11
I/LnJ	Mean	39.4	181.8^#	8,125	7,505^*	1.40	13.20^#	5,481	3,970^*	23,856	2,128
	sem	3.7	19.9	360	319	0.21	2.16	454	218	193	557
	n	4	6	4	6	4	6	4	6	4	6
KK/HlJ	Mean	68.3	142.1	15,625	22,353	0.00	5.58^*	10,725	12,729^*	3,025	5,619^*
	sem	12.6	11.5	2,113	1,711	0	2.86	1,475	2,366	225	190
	n	8	17	8	17	3	4	3	4	3	4
MA/MyJ	Mean	108.3	184.7^#	19,167	17,763^*	2.27	5.43^*	14,369	11,501^*	4,698	4,356^*
	sem	11.8	22.6	1,758	1,561	1.22	1.21	1,562	1,176	527	548
	n	9	19	6	19	5	11	5	11	5	11
MOLF/EiJ	Mean	89.0	116.3	16,250	9,722^*	0.58	5.00^*	10,806	2,996^*	5348	1,783^*
	sem	33	21	2,339	1,455	0.38	1.69	1,682	454	926	777
	n	4	9	4	9	4	3	4	3	4	3
MRL/MpJ	Mean	77.6	137.5	25,078	24,196	1.07	6.55	25,813	16,049^*	7,131	5,967^*
	sem	8.4	9.0	1,994	1,270	0.30	1.01	6,899	1,791	1,464	712
	n	17	28	16	28	6	7	6	7	6	7
NOR/LtJ	Mean	68.4	161.9^#	19,083	23,529	0.85	6.02^*	19,861	15,041^*	3,946	7,284
	sem	5.7	9.0	1,995	1,658	0.30	1.31	2,279	1,637	387	1,050
	n	15	17	15	17	4	5	4	5	4	5
NZO/HlLtJ	Mean	67.1	157.5^#	19,583	19,844^*	2.23	8.90	15,703	13,301^*	3,432	5,059^*
	sem	4.6	7.1	2,732	3,138	0.29	4.08	1,742	2,756	878	1,249
	n	3	7	3	8	3	4	3	4	3	4
NZW/LacJ	Mean	79.7	148.1	37,188	52,250^#	0.25	7.28	32,965	46,611^#	6,359	6,413
	sem	7.0	8.7	3,673	6,957	0.17	2.94	4,250	7,970	1,301	762
	n	8	10	8	10	4	7	4	7	4	7
P/J	Mean	92.1	136.7	8,875	20,987	3.67	18.07^#	8,824	12,417^*	4,492	11,754^#
	sem	12.5	15.5	1,723	4,579	0.79	5.30	2,382	3,944	1,223	4123
	n	11	21	10	19	7	7	7	7	7	7
PL/J	Mean	86.3	173.9^#	24,531	25,417	6.00	6.15	21,213	16,614^*	5,568	2,849^*
	sem	14.7	28.8	2,302	1,916	5.02	1.29	318	2,710	1,331	622
	n	8	15	8	15	3	9	3	9	3	9
PWD/PhJ	Mean	58.6	166.1^#	12,375	24,375	5.48	17.85^#	8,555	13,834^*	3,379	5,638^*
	sem	13.4	24.7	1,782	2,767	2.75	2.80	1,591	2,648	858	443
	n	10	14	10	12	4	10	4	10	4	10
PWK/PhJ	Mean	55.8	167.9^#	10,446	17,188^*	0.14	20.07^#	6,595	9,996^*	4,286	4,821^*
	sem	5.9	17.8	968	1,306	0.10	2.08	1,066	1,352	337	589
	n	15	27	14	28	7	16	7	16	7	16
RIIIS/J	Mean	84.4	88.8^*	22,031	20,909	0.96	1.71^*	13,610	14,098^*	4,862	5,391^*
	sem	7.2	9.5	1,844	1,328	0.19	0.40	664	2,078	1,374	206
	n	8	10	8	11	5	7	5	7	5	7
SJL/J	Mean	57.1	104.6^*	13,000	18,125^*	2.26	8.96	8,890	9,304^*	3,780	6,832
	sem	7.1	15.5	1,090	3,143	0.73	1.47	773	1,982	432	148
	n	5	7	5	8	5	7	5	7	5	7
SM/J	Mean	37.3	112.9	14,688	17,143^*	1.57	7.13	10,167	11,627^*	2,665	3,016^*
	sem	3.0	16.1	1,386	1,630	0.47	0.99	546	1,041	205	155
	n	4	10	4	7	3	6	3	6	3	6
SWR/J	Mean	47.0	80.7^*	30,938	51,618^#	0.50	1.64	27,227	38,336^#	3,560	8,980^#
	sem	7.5	11.6	2,571	6,033	0.22	0.46	2,666	6,036	200	1,072
	n	7	17	4	17	4	13	4	13	4	13
WSB/EiJ	Mean	35.9	85.0^*	16,250	22,292	0.77	4.89^*	15,061	16,485^*	3,631	4,674
	sem	3.1	13.3	4,705	2,509	0.77	1.42	5,012	1,515	687	806
	n	4	8	4	6	3	7	3	6	3	6

For each strain, the phenotypic mean, sem, and sample size (n) for the phenotypes are listed. Air, filtered room air exposure for 4 d; O₂, 3 d of hyperoxia exposure.

P < 0.05 vs. highest-responding strain;

P < 0.05 vs. lowest-responding strain.