Table 3.

Candidate susceptibility genes in QTLs for hyperoxia-induced inflammation in neonatal mouse lungs

QTL	Gene symbol	SNP
		rs ID	Location (Mb)a	AA change	Major allele	Minor allele	P
Hsnl1	Cyp2j11	28105291	95.961592	I 476 V	T, 21.6 ± 1.8a	C, 7.7 ± 2.6a	0.0005
	Cyp2j6	28120055	96.202243	C 192 F	C, 21.6 ± 1.8a	A, 7.7 ± 2.6a	0.0005
	Cyp2j9	28119885	96.252622	I 90 V	T, 22.1 ± 1.8a	C, 7.6 ± 2.0a	0.0003
		28119867	96.257924	R 37 L	C, 21.8 ± 1.8a	A, 6.0 ± 1.6a	0.0003
	Cyp2j5	28119831	96.300844	P 394 T	C, 21.8 ± 1.8a	A, 6.1 ± 1.6a	0.0003
Hsnl2	Mgmt	33644808	144.143061	L 32 F	G, 22.1 ± 1.8a	T, 7.6 ± 2.0a	<0.0001
		33669425	144.277666	G 53 C	G, 24.8 ± 2.6a	T, 14.1 ± 1.5a	0.0030
Hsnl4	Chrm2	30378838	36.474006	P 265 L	C, 9.4 ± 0.9b	T, 4.0 ± 0.6b	<0.0001

Candidate susceptibility genes are indicated according to QTL. Locations are from build 37. All SNPs resulting in an amino acid (AA) change are listed for each gene. Phenotypic means ± se for the respective QTL phenotype for strains having the major or minor allele are reported; P values indicate significant differences between allelic groups.

^aMacrophages ×10³.

^bPercentage PMNs.