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The cadherin switch observed upon BRAF knockdown requires Tiam1. WM793 cells (A) or WM115 cells (B) were transfected with control, BRAF, V600E and Tiam1 (A, B) or Vav2 (C) siRNA. N-cadherin and E-cadherin expression were analyzed by Western blotting. Actin was used as a loading control. The levels of BRAF and Tiam1 (A,B) or Vav (C) were checked to confirm knockdown.
