Table 4. Stratified analysis of high CD4⁺ TIL Levels in combination with low CD8⁺ TIL levels for overall survival and progress-free survival in glioblastoma patients.

	Multivariate analysis
	Overall survival			Progress-free survival
Subgroups	P	HR	95% CI	P	HR	95% CI
MGMT promoter status
Methylated	0.015	1.889	1.129–3.158	0.001	2.613	1.496–4.561
Unmethylated	0.008	1.590	1.127–2.243	0.011	1.591	1.110–2.281
Age
Age<47	0.063	1.389	0.982–1.965	0.027	1.541	1.049–2.262
Age⩾47	<0.001	2.308	1.494–3.566	0.001	1.813	1.261–2.609
KPS
KPS<80	0.002	3.291	1.567–6.914	0.014	1.915	1.143–3.210
KPS⩾80	0.043	1.392	1.011–1.918	0.006	1.599	1.143–2.237

Abbreviations: CI=confidence interval; HR=hazard ratio; KPS=Karnofsky performance status; MGMT=O(6)-methylguanine-DNA-methyltransferase.