Table 3. Multivariate regression analysis.
| Factors | OR | 95% CI | P |
|---|---|---|---|
| Tumour-infiltrating lymphocyte(TIL+) |
5.92 |
1.69–20.78 |
0.005a |
| Prechemotherapy HAGE (+) |
4.55 |
1.26–16.44 |
0.021a |
| Top2A (+) |
4.53 |
1.10–18.88 |
0.038a |
| Triple negative (+) |
3.1 |
0.84–11.46 |
0.091 |
| Clinical TNM stage (II vs III) |
0.97 |
0.22–4.25 |
0.964 |
| Tumour grade (G1/2 vs G3)** |
0.4 |
0.13–1.25 |
0.114 |
| Maximum diameter of prechemotherapy tumour size (continuous) |
1.01 |
0.99–1.04 |
0.422 |
| Patient age (continuous) | 1.03 | 0.96–1.09 | 0.426 |
Abbreviations: CI=confidence interval; HAGE=helicase antigen; OR=odds ratio; TNM=Tumour, Node, Metastases; TOP2A=topoisomerase (DNA) II alpha.
TIL, HAGE and TOP2A are independent predictors for pathological complete response.
**Nottingham histological grading system.
a
Statistically significant.