Table 1. Patient's demographics according to LAT1, ASCT2, and xCT expression.
| |
|
LAT1 |
ASCT2 |
xCT |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable | Total (n=85) | High (n=52) | Low (n=33) | P-value | Positive (n=50) | Negative (n=35) | P-value | Positive (n=18) | Negative (n=67) | P-value |
|
Age | ||||||||||
| ⩽65 years/>65 years |
36/49 |
19/33 |
17/16 |
0.185 |
18/32 |
18/17 |
0.184 |
7/11 |
29/38 |
0.793 |
|
Sex | ||||||||||
| Male/Female |
56/29 |
34/18 |
22/11 |
>0.999 |
31/19 |
25/10 |
0.486 |
12/6 |
44/23 |
>0.999 |
|
Differentiation | ||||||||||
| WD or MD/PD |
73/11 |
43/9 |
30/3 |
0.353 |
42/10 |
31/4 |
0.753 |
14/4 |
59/8 |
0.271 |
|
Stage | ||||||||||
| I or II/III or IV |
50/35 |
26/26 |
24/9 |
0.044 |
26/24 |
30/5 |
0.001 |
7/11 |
49/18 |
0.011 |
|
Primary tumour status | ||||||||||
| T1-2/T3-4 |
72/13 |
42/10 |
30/3 |
0.236 |
40/10 |
34/1 |
0.023 |
11/7 |
63/4 |
0.001 |
|
Lymph-node status | ||||||||||
| N0/N1-2 |
31/54 |
27/ 25 |
4/29 |
<0.001 |
28/22 |
8/27 |
0.004 |
10/8 |
20/47 |
0.054 |
|
Lymphatic permeation | ||||||||||
| Positive/Negative |
37/48 |
30/22 |
7/26 |
<0.001 |
27/33 |
11/24 |
0.047 |
11/7 |
27/40 |
0.181 |
|
Vascular invasion | ||||||||||
| Positive/Negative |
26/59 |
22/30 |
4/29 |
0.003 |
20/30 |
7/28 |
0.061 |
6/12 |
21/46 |
>0.999 |
|
Resected status | ||||||||||
| Positive/Negative |
15/70 |
11/41 |
4/29 |
0.383 |
10/40 |
5/30 |
0.573 |
4/14 |
11/56 |
0.727 |
|
Adjuvant CTx | ||||||||||
| Yes/No |
24/61 |
19/33 |
5/28 |
0.047 |
17/33 |
7/28 |
0.221 |
7/11 |
17/50 |
0.376 |
|
4F2hc | ||||||||||
| High/Low |
38/47 |
33/19 |
5/28 |
<0.001 |
27/23 |
11/24 |
0.048 |
12/6 |
26/41 |
0.059 |
|
Ki-67 | ||||||||||
| High/Low |
43/42 |
33/19 |
10/23 |
0.003 |
29/21 |
11/24 |
0.026 |
11 /7 |
29/38 |
0.195 |
|
CD34 | ||||||||||
| High/Low |
44/41 |
33/19 |
11/22 |
0.008 |
26/24 |
16/19 |
0.661 |
10/8 |
32/35 |
0.604 |
|
p53 | ||||||||||
| Positive/Negative | 37/48 | 25/27 | 12/21 | 0.370 | 21/29 | 17/18 | 0.658 | 8/10 | 30/37 | >0.999 |
Abbreviations: ASCT2=ASC amino-acid transporter 2; CTx=chemotherapy; LAT1=L-type amino-acid transporter 1; MD=moderate differentiated; PD=poorly differentiated; WD=well differentiated.
The bold entries show a statistically significant difference.