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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Biochim Biophys Acta. 2014 Mar 13;1843(6):1216–1224. doi: 10.1016/j.bbamcr.2014.03.005

Figure 2.

Figure 2

TMEFF2 inhibits RWPE2 cell spreading on tissue culture plates. A) Representative images of cell morphology of RWPE2 cells expressing different forms of the TMEFF2 protein, or the empty vector, on tissue culture surface. Arrows point to rounded cells. Scale bars, 100 μm. B) Quantification of round cells at 3 h after seeding 40,000 cells/well in a 12-well plate. Data are presented as mean ± SD of three independent experiments. C) Representative images of cell morphology of RWPE2 cells expressing the inducible FL_TMEFF2 before and after the addition of doxycycline. Note that FL_TMEFF2 expression promotes cell rounding and those cells lack lamellipodia.