Table 2.
Attempted suicide replication and meta-analysis results
Chromosome Region | Best SNP in Region | RefSeq1 Gene | RefSeq Genes in LD | Initial Odds Ratio2 | Initial P-value | Replication Odds Ratio2 | Replication P-value | Combined P-value |
---|---|---|---|---|---|---|---|---|
2p25 | rs300774 | Intergenic | SH3YL1, ACP1, FAM150B | 1.42 | 1.09 × 10−6 | 1.22 | 0.0036 | 5.07 × 10−8 |
11p13 | rs10437629 | C11orf41 | None | 1.62 | 8.56 × 10−5 | 1.34 | 0.0078 | 3.77 × 10−6 |
12q24 | rs7296262 | TMEM132C | None | 1.43 | 9.08 × 10−6 | 1.22 | 0.011 | 1.09 × 10−6 |
Indicates whether the SNP localizes to a known RefSeq gene or to an intergenic region (UCSC Genome Browser, March 2006).
The odds ratio is provided for the minor allele from a logistic regression analysis under an additive model.