(a)
| Agonist | Targeted cell | Response of cell |
|---|---|---|
| PAR-1 | ||
| Thrombin | PBMC [47]; A549 [92, 93]; Mon [94]; TC [95]; HPDF [96, 97]; CHAEC [98, 99]; EnC [54] | IL-1β [47], IL-6 [47, 94, 95], IL-8 [92, 96], MCP-1 [93], MMP-9 [97], MMP-12 [99], VCAM-1 [54], VEGF [98] |
| Trypsin | A549 [92, 93]; Mon [94]; TC [95] | Release of IL-8 [92]; MCP-1 [93]; IL-6 [94, 95] |
| SFLLR-NH2 | A549 [58, 92, 93]; Mon [94]; HBEC [58]; TC [95]; CHAEC [98, 99] | IL-8 [92]; MCP-1 [93]; IL-6 [94, 95]; PGE2 [58]; VEGF [98]; MMP-12 [99] |
|
| ||
| PAR-2 | ||
| Tryptase | A549 [92, 93]; Neu [38]; Mon [94]; TC [95]; Astr [111] | Release of IL-8 [38, 92]; MCP-1 [93]; IL-6 [94, 95, 111]; LF [38];TNF-α, ROS [111] |
| Trypsin | A549 [92, 93]; Mon [94]; HPBF [68]; Eos [35]; MC [107]; HUVEC [108] | Release of IL-8 [68, 92, 108]; MCP-1 [93]; IL-6 [94]; G-CSF, VCAM-1 [68]; sys-LT, ROS [35]; tryptase [107] |
| Elastase | A549 [92, 93]; AEC [101]; Mon [94] | Release of IL-8 [92]; MCP-1 [93]; IL-6 [94]; MUC5AC [101] |
| GCE | MH-S [49]; RAW264.7 [49] | TNF-α [49] |
| WCE | PHKC [104] | Release of IL-8, GM-CSF [104] |
| SLIGKV-NH2 | A549 [58, 92, 93]; HPBF [68]; HBEC [58]; TC [95]; HTEC [102]; Kerat [103]; Neu [38]; Eos [35, 36]; MC [107]; BEAS-2B, Calu-3 [109] | Release of IL-8 [38, 68, 92, 109]; MCP-1 [93]; PGE2 [58]; IL-6 [95, 109]; G-CSF [68]; VCAM-1 [68, 102]; GM-CSF [102, 109]; TNF-α [102]; MMP-1,10 [102]; TSLP [103]; LF [38]; sys-LT, ROS [35]; SOD [36]; His [107] |
| tc-LIGRLO-NH2 | Neu [38]; MC [107] | Release of IL-8, LF [38]; His [107] |
|
| ||
| PAR-3 | ||
| Thrombin | A549 [92, 93]; Mon [94]; EnC [54] | Release of IL-8 [92]; MCP-1 [93]; IL-6 [94]; ICAM-1, VCAM-1 [54] |
|
| ||
| PAR-4 | ||
| Thrombin | A549 [92, 93]; Mon [94] | Release of IL-8 [92]; MCP-1 [93]; IL-6 [94] |
| GYPGQV-NH2 | A549 [58, 92, 93]; Mon [94]; HBEC [58] | IL-8 [92]; MCP-1 [93]; IL-6 [94]; PGE2 [58] |