Table 1.
Characteristics of the hypercholesterolemic and normolipemic groups
| Polygenic hypercholesterolemia (n=477) | Normolipemics (n=525) | P value* | |
|---|---|---|---|
|
Men (%) |
57.4 |
90.9 |
< 0.001 |
|
Age (years) |
51 (41-56) |
51 (42-54) |
0.004 |
|
BMI (kg/m
2
) |
26 (24-28) |
27 (25-29) |
< 0.001 |
|
Waist circumference (cm) |
92 (84-98) |
95 (88-101) |
< 0.001 |
|
Smoking status (%) |
|
|
0.019 |
| Active smokers |
24.8 |
37.3 |
|
| Non-smokers |
49.9 |
37.0 |
|
| Past smokers |
25.3 |
25.7 |
|
|
Hypertension (%) |
20.7 |
20.2 |
0.885 |
|
Laboratory variables (mg/dL) |
|
|
|
| Fasting glucose |
91 (84-98) |
94 (87-102) |
< 0.001 |
| Total cholesterol |
290 ± 42 |
202 ± 32 |
< 0.001 |
| Triglycerides |
108 (83-137) |
100 (72-136) |
0.019 |
| HDL-cholesterol |
53 (46-65) |
53 (47-61) |
0.026 |
| LDL-cholesterol |
207 (186-231) |
127 (107-147) |
< 0.001 |
| Lipoprotein(a) |
29 (13-63) |
19 (8-51) |
< 0.001 |
| Apolipoprotein B | 148 ± 27 | 97 ± 22 | < 0.001 |
Data shown for quantitative variable when normal distribution are means ± SD or median and interquartile range for variables with non-normal distribution. Data shown for qualitative variable are percentages. *Calculated by unpaired t-test or Mann–Whitney U–test, as appropriate.