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. 2008 Nov;1(1):55–63. doi: 10.15283/ijsc.2008.1.1.55

Fig. 1.

Fig. 1.

How do HSCs affect peripheral immunity? Lymphocytes in peripheral blood are generated from bone marrow HSCs. Aging of HSCs ultimately affects peripheral immunity through the accumulation of DNA damage, and epigenetic and lineage dysregulation.