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. 2008 Nov;1(1):55–63. doi: 10.15283/ijsc.2008.1.1.55

Fig. 2.

Fig. 2.

Change in HSC phenotype during the aging process. Since lymphoid genes are decreased and myeloid genes are increased by aging, the phenotypic shift from the lymphoid to the myeloid lineage of in aged HSCs ultimately contributes to immune dysfunction and the decline of adaptive immunity.