Table 2.
Representative gene profiles during HSC aging
| Function | Expression during aging | Reference |
|---|---|---|
| Protein folding/stress | Increase | Stuart M. Chambers et al., 2007. |
| Inflammation/proteolysis/cell-cell adhesion | Increase | |
| APP processing/Alzheimer | Increase | |
| Stress response/Senescence | Increase | |
| DNA repair | Decrease | |
| TGF β reglation/HSCs pool size change | Decrease | |
| Chromatic silencing | Decrease | |
| Deficiency/Mutation cause progeria | Decrease |
Genes that regulate DNA repair and HSC pool size are decreased by aging, and those involved in protein folding or stress response, inflammation, and senescence-related are increased.