Table 1.
Factors/cytokines affecting angiogenesis
| Stimulation | Inhibition |
|---|---|
| Hypoxia | Angiostatin |
| Nitric oxide | Endostatin |
| Hypoxia inducible factor-1 (HIF-1) | Troponin-I |
| Vascular endothelial growth factor (VEGF) | Thromboplastin |
| Acid and basic fibroblast growth factor (FGF) | Tissue inhibitors of matrix metalloproteinase (TIMPs) |
| Angiopoietin 1 (ANG-1) | Suramin |
| Platelet derived growth factor (PDGF) | |
| Hepatocyte growth factor (HGF) | |
| Granulocyte macrophage-colony stimulating factor (GM-CSF) | |
| Monocyte chemotactic protein-1 (MCP-1) | |
| Transforming growth factor (TGF)α&β | |
| Tumor necrosis factor (TNF)α |