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. 2014 May 14;4:4965. doi: 10.1038/srep04965

Figure 5. Selective compounds enhance BMP-2 signaling responsiveness.

Figure 5

(a) Selective compounds increased BMP-2 responsible reporter gene activity. Data points were determined in triplicate and showed with the mean ± SD (*: p < 0.05, t-test). (b) Selective compounds increased ALP, osteocalcin and type I collagen (α1) expression in mouse myoblasts. C2C12 cells were treated A01 and A17 at 2 μM, while rhBMP-2 was used at 50 ng/ml. Data points were determined in triplicate and showed with the mean ± SD (*: p < 0.05, t-test). (c) Selective compounds increased ALP, osteocalcin and type I collagen (α1) expressions in mouse pre-osteoblasts. MC3T3-E1 cells were treated A01 and A17 at 2 μM, while rhBMP-2 was used at 50 ng/ml. Data points were determined in triplicate and showed with the mean ± SD (*: p < 0.05, t-test).