Table 3.
Baseline blood pressure factors associated with antihypertensive drug changes, CoLaus study
| |
Continuers |
Combiners |
Switchers |
Discontinuers |
p-value |
|---|---|---|---|---|---|
| N | 420 (54.4) | 208 (26.9) | 98 (12.7) | 46 (6.0) | |
| BP status baseline |
|
|
|
|
|
| SBP (mm Hg) |
137 ± 17 |
146 ± 19 |
138 ± 16 |
137 ± 15 |
<0.001 |
| DBP (mm Hg) |
83 ± 11 |
86 ± 12 |
83 ± 11 |
83 ± 9 |
<0.05 |
| Hypertension§ |
220 (52.4) |
138 (66.4) |
54 (55.1) |
20 (43.5) |
<0.001 |
| Antihypertensive drug |
|
|
|
|
|
| Diuretics (%) |
236 (56.2) |
64 (30.8) |
47 (48.0) |
15 (32.6) |
<0.001 |
| Beta-blockers (%) |
120 (28.6) |
50 (24.0) |
30 (30.6) |
16 (34.8) |
0.38 |
| CCB (%) |
76 (18.1) |
42 (20.2) |
23 (23.5) |
5 (10.9) |
0.30 |
| ACE inhibitors (%) |
119 (28.3) |
58 (27.9) |
32 (32.7) |
13 (28.3) |
0.84 |
| ARBs (%) |
224 (53.3) |
82 (39.4) |
26 (26.5) |
13 (28.3) |
<0.001 |
| Treatment regimen (%) |
|
|
|
|
|
| One pill, single drug |
155 (36.9) |
132 (63.5) |
49 (50.0) |
32 (69.6) |
|
| One pill, combination |
119 (28.3) |
34 (16.4) |
26 (26.5) |
7 (15.2) |
<0.001 |
| Several pills | 146 (34.8) | 42 (20.2) | 23 (23.5) | 7 (15.2) |
Results are expressed as mean ± standard deviation or as number of participants and (percentage). §defined as a systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg if absence of diabetes, or as a systolic blood pressure ≥130 mm Hg or diastolic blood pressure ≥80 mm Hg if presence of diabetes. CCB, calcium channel blockers; ACE, angiotensin converting enzyme; ARB, angiotensin receptor blockers. Statistical analysis comparing all groups by Chi-square or one-way analysis of variance.