Table 1. Clinical and pathological characteristics of 1426 consecutive colorectal cancer patients (2004–2009).
| Variable | Count (%) unless otherwise stated | Single variable P-valuea | Univariate analysis HR (95% CI), P-value | Multivariate analysis HR (95% CI), P-value |
|---|---|---|---|---|
| Gender | 0.13 | |||
| Female | 743 (52.1) | 1.00 | 1.00 | |
| Male | 683 (47.9) | 0.82 (0.67–1.01), 0.07 | 1.24 (0.94–1.65), 0.13 | |
| Age at diagnosis, median (range) | 74 (17–100) | 1.03 (1.02–1.04), <0.01 | 1.04 (1.03–1.05), <0.01 | |
| Anatomic location | <0.01 | |||
| Rectum | 363 (25.4) | 1.00 | 1.00 | |
| Cecum | 312 (21.9) | 1.36 (1.00–1.85), 0.05 | 1.08 (0.72–1.62), 0.71 | |
| Ascending colon | 219 (15.3) | 1.22 (0.85–1.75), 0.29 | 1.00 (0.62–1.62), 0.99 | |
| Transverse colon | 168 (11.8) | 1.95 (1.37–2.77), <0.01 | 1.17 (0.72–1.90), 0.54 | |
| Descending colon | 51 (3.6) | 1.65 (0.96–2.83), 0.07 | 0.88 (0.42–1.86), 0.74 | |
| Sigmoid colon | 302 (21.2) | 1.14 (0.83–1.58), 0.42 | 1.02 (0.67–1.55), 0.93 | |
| Histologic grade | <0.01 | |||
| Low | 826 (57.9) | 1.00 | 1.00 | |
| High | 214 (15.0) | 1.87 (1.42–2.47), <0.01 | 1.27 (0.87–1.84), 0.21 | |
| Lymphovascular space invasion | 0.02 | |||
| Absent | 538 (37.7) | 1.00 | 1.00 | |
| Present | 459 (32.2) | 2.26 (1.72–2.95), <0.01 | 1.57 (1.13–2.19), <0.01 | |
| Peritumoral lymphocyte reaction | <0.01 | |||
| Absent | 45 (3.2) | 1.00 | 1.00 | |
| Present | 999 (70.1) | 2.21 (0.91–5.37), 0.08 | 1.90 (0.74–4.89), 0.18 | |
| Overall stage AJCC/TNM 7th edn | <0.01 | |||
| I | 235 (16.5) | 1.00 | 1.00 | |
| IIA | 415 (29.1) | 2.00 (1.30–3.17), <0.01 | 2.21 (1.20–4.11), 0.01 | |
| IIB | 85 (6.0) | 2.44 (1.34–4.42), <0.01 | 2.66 (1.20–5.89), 0.02 | |
| IIC | 15 (1.1) | 9.66 (4.17–22.40), <0.01 | 11.93 (4.68–30.41), <0.01 | |
| IIIA | 64 (4.5) | 1.10 (0.50–2.43), 0.82 | 0.94 (0.27–3.33), 0.93 | |
| IIIB | 376 (26.3) | 3.05 (1.97–4.72), <0.01 | 2.75 (1.49–5.08), <0.01 | |
| IIIC | 174 (12.2) | 6.48 (4.12–10.17), <0.01 | 5.85 (3.11–11.02), <0.01 | |
| IVA | 32 (2.2) | 8.06 (4.24–15.31), <0.01 | 11.76 (4.88–28.32), <0.01 | |
| IVB | 30 (2.1) | 14.10 (7.47–26.64), <0.01 | 15.86 (6.71–37.48), <0.01 | |
| Mismatch repair IHC status | <0.01 | |||
| Proficient | 1148 (80.5) | 1.00 | ||
| Deficient | 278 (19.5) | 0.74 (0.55–0.99), 0.04 | ||
| BRAFV600E immunohistochemistry status | <0.01 | |||
| Wild type | 1151 (80.7) | 1.00 | ||
| Mutant | 275 (19.3) | 1.14 (0.88–1.49), 0.32 | ||
| Immunhoistochemistry phenotypes | <0.01 | |||
| Mismatch repair-proficient/BRAF wild type | 1057 (74.1) | 1.00 | 1.00 | |
| Mismatch repair-deficient/BRAFV600E mutant | 184 (12.9) | 0.84 (0.60–1.19), 0.32 | 0.57 (0.35–0.93), 0.03 | |
| Mismatch repair-deficient/BRAF wild type | 94 (6.6) | 0.66 (0.40–1.08), 0.10 | 0.65 (0.34–1.27), 0.21 | |
| Mismatch repair-proficient/BRAFV600E mutant | 91 (6.4) | 1.79 (1.24–2.60), <0.01 | 1.10 (0.69–1.76), 0.68 |
a
Reports on the significance of differences between two or more categories within each variable as a one sample non-parametric binomial or χ2-test.