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Schematic models for membrane deformation, based on the geometries of basic-charged amino acid residues that correspond to the structures of the membrane-binding surface of the F-BAR domain-containing proteins. (A) BAR or F-BAR proteins bind to the membrane to generate invaginations, such as caveolae and clathrin-coated pits; (B) I-BAR proteins deform the membrane to generate protrusions, such as filopodia and lamellipodia.
