Table 4.
Comparison of different prediction scales on short-term mortality on patients with eCOPD
|
Outcome |
N |
Short-term mortality |
P
value* |
AUC |
95% CI |
P
value** |
|
|---|---|---|---|---|---|---|---|
| Yes | No | ||||||
| DeCOPD score mean (sd) |
2484 |
9.03 (4.27) |
3.07 (3.4) |
≤0.0001 |
0.85 |
0.79 to 0.90 |
Refa |
| DeCOPD score (categorical) |
2484 |
|
|
≤0.0001 |
0.84 |
0.79 to 0.89 |
0.38 |
| Risk |
|
|
|
|
|
|
|
| Mild |
1081 |
3 (0.28) |
1078 (99.72) |
|
|
|
|
| Moderate |
865 |
11 (1.27) |
854 (98.73) |
|
|
|
|
| Severe |
441 |
20 (4.54) |
421 (95.46) |
|
|
|
|
| Very severe |
97 |
24 (24.74) |
73 (75.26) |
|
|
|
|
| GOLD FEV1% |
2069 |
|
|
0.0133 |
0.62 |
0.56 to 0.69 |
<0.0001 |
| FEV1% ≥80 |
76 |
0 (0.0) |
76 (100) |
|
|
|
|
| 50 ≤ FEV1% <80 |
643 |
6 (0.93) |
637 (99.07) |
|
|
|
|
| 30 ≤ FEV1% <50 |
959 |
28 (2.92) |
931 (97.08) |
|
|
|
|
| FEV1% ≤30 |
391 |
13 (3.32) |
378 (96.68) |
|
|
|
|
| GOLD COPD combined assessment |
2090 |
|
|
<0.002 |
0.71 |
0.67 to 0.75 |
<0.0001 |
| Low risk, low symptom burden |
286 |
1 (0.35) |
285 (99.65) |
|
|
|
|
| Low risk, higher symptom burden |
335 |
4 (1.19) |
331 (98.81) |
|
|
|
|
| High risk, low symptom burden |
351 |
0 (0.00) |
351 (100) |
|
|
|
|
| High risk, higher symptom burden |
1118 |
46 (4.11) |
1072 (95.89) |
|
|
|
|
| HADO score |
1887 |
|
|
0.0002 |
0.68 |
0.63 to 0.72 |
<0.0001 |
| Mild (<4) |
188 |
0 |
188 (100) |
|
|
|
|
| Moderate (5 to 7) |
604 |
3 (0.50) |
601 (99.50) |
|
|
|
|
| Severe (>8) |
1095 |
33 (3.01) |
1062 (96.99) |
|
|
|
|
| ADO index (0 to 14) mean (sd) | 2067 | 11.36 (1.71) | 9.29 (2.19) | ≤0.0001 | 0.78 | 0.71 to 0.84 | 0.05 |
Abbreviations: ADO age, baseline dyspnea, and airflow obstruction; AUC, area under the curve; COPD, chronic obstructive pulmonary disease; DeCOPD, Death in exacerbation of chronic obstructive pulmonary disease; ED, emergency department; FEV, forced expiratory volume; GOLD, Global Initiative for Chronic Obstructive Lung Disease; HADO, health, activity, dyspnea, and airflow obstruction; LTHOT; long-term home oxygen therapy; MRC, Medical Research Council; NIMV, non-invasive mechanical ventilation; PCO2 carbon dioxide partial pressure; PO2, oxygen partial pressure.
aReference value.
*p-value of the relationship of each parameter with short-term mortality.
**p-value or the comparison of areas under Receiver Operating Characteristic Curves with respect to the AUC of the DECOPD continuous scale.