Table 4.
Variables predicting subclinical atherosclerosis in non-diabetic men with HIV infection
| Multiple stepwise regression | ||||||
|---|---|---|---|---|---|---|
| Mean right CC IMT | Maximum right CC IMT | |||||
| B | r2 | p | B | r2 | p | |
| 0.45 | <0.001 | 0.26 | 0.03 | |||
| Age (10 years) | 0.06 | 0.004 | 0.05 | 0.05 | ||
| Duration of HIV (years) | ||||||
| HIV-VL RNA/mL <39 (yes) | ||||||
| PIs exposure (years) | 0.02 | 0.001 | 0.014 | 0.03 | ||
| NRTI exposure (years) | −0.07 | 0.2 | ||||
| NNRTI exposure (years) | ||||||
| BMI (kg/m2) | −0.002 | 0.7 | 0.007 | 0.3 | ||
| WHR | −0.06 | 0.8 | −0.31 | 0.4 | ||
| Lipodystrophy (yes) | −0.02 | 0.5 | 0.016 | 0.7 | ||
| FG (mmol/L) | ||||||
| HbA1c (%) | 0.07 | 0.058 | 0.07 | 0.14 | ||
| IFG (yes) | 0.03 | 0.3 | ||||
| TG (mmol/L) | ||||||
| hsRCP (mg/dL) | 0.04 | 0.3 | ||||
| PAI-1 (ng/L) | 0.01 | 0.1 | 0.01 | 0.1 | ||
| IL-6 (pg/L) | ||||||
| Vitamin D insufficiency (yes) | −0.03 | 0.4 | −0.01 | 0.8 | ||
| Constant | 0.12 | 0.6 | 0.26 | 0.3 | ||
| Mean left CC IMT | Maximum left CC IMT | |||||
| B | r 2 | p | B | r 2 | p | |
| 0.44 | 0.003 | 0.48 | <0.001 | |||
| Age (10 years) | 0.05 | 0.01 | 0.07 | 0.004 | ||
| Duration of HIV (years) | −0.02 | 0.6 | −0.006 | 0.8 | ||
| HIV-VL RNA/mL <39 cop.(yes) | −0.03 | 0.4 | −0.02 | 0.5 | ||
| PIs exposure (years) | 0.007 | 0.2 | 0.01 | 0.3 | ||
| NRTI exposure (years) | 0.006 | 0.3 | 0.01 | 0.35 | ||
| NNRTI exposure (years) | −0.005 | 0.6 | ||||
| BMI (kg/m2) | −0.003 | 0.5 | ||||
| WHR | 0.04 | 0.9 | −0.32 | 0.2 | ||
| Lipodystrophy (yes) | −0.03 | 0.4 | −0.02 | 0.5 | ||
| FG (mmol/L) | −0.003 | 0.2 | 0.005 | 0.13 | ||
| HbA1c (%) | 0.05 | 0.1 | 0.06 | 0.1 | ||
| IFG (yes) | 0.1 | 0.03 | 0.13 | 0.01 | ||
| TG (mmol/L) | 0.0001 | 0.4 | ||||
| hsRCP (mg/L) | −0.00001 | 0.9 | ||||
| PAI-1 basal (ng/L) | 0.006 | 0.2 | 0.009 | 0.07 | ||
| IL-6 (pg/L) | 0.004 | 0.2 | 0.006 | 0.1 | ||
| Vitamin D insufficiency (yes) | −0.01 | 0.8 | −0.04 | 0.39 | ||
| Constant | 0.46 | 0.12 | 0.77 | 0.02 | ||
Dependent variables are in bold; explanatory variables with statistically significant results in multiple regression analysis and their significance are in bold. CC, common carotid; IMT, intima-media thickness; B, standardized coefficient; r2, coefficient of determination; BMI, body mass index; WHR, waist-hip ratio; NRTI, nucleoside reverse transcriptase inhibitor; PI, protease inhibitor; FG, fasting glucose; IFG, impaired fasting glucose (plasma glucose ≥5.55 mmol/L); TG, triglycerides; hsRCP, high-sensitivity reactive C protein; PAI-1, plasminogen activator inhibitor-1; IL-6, interleukin 6.