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. 2014 Apr 29;2014:463058. doi: 10.1155/2014/463058

Table 3.

Results.

Total
774 patients
First period
January 2002–March 2006
(n = 210)
Second period
April 2006–February 2009
(n = 267)
Third period
March 2009–December 2010
(n = 297)
P value
Pregnancies 128 (16.5%) 48 (22.8%) 65 (24.3%) 15 (5.0%) P < 0.0001 S
Dyspareunia 116 (14.9%) 9 (4.2%) 29 (10.8%) 78 (26.2%) P < 0.0001 S
Constipation 162 (21%) 18 (8.5%) 54 (20.2%) 90 (30.3%) P < 0.0001 S
Diarrhoea 57 (7.3%) 4 (1.9%) 16 (5.9%) 27 (9.1%) P = 0.004 S
Rectal bleeding 47 (6.0%) 19 (9.0%) 12 (4.5%) 16 (5.3%) P = 0.097 NS
Pelvic pain 64 (8%) 3 (1.4%) 18 (6.7%) 46 (15.4%) P < 0.0001 S
Dysuria 114 (14.7%) 31 (14.7%) 34 (12.7%) 49 (16.4%) P = 0.452 NS