12. Monotherapy versus combination therapy risk differences for children with SAE of any cause.

Children with an all‐cause SAE (pooled risk differences, M‐H Random)
LABA monotherapy		Placebo		Risk Difference (95% CI)	Heterogeneity (I‐squared)
Children with SAE	Total	Children with SAE	Total
80	1568	40	1100	0.0191 (0.0061, 0.0321)	15%
LABA combination therapy		ICS		Risk Difference (95% CI)	Heterogeneity (I‐squared)
Children with SAE	Total	Children with SAE	Total
31	2649	14	2001	0.0017 (‐0.0037, 0.0070)	2%