Skip to main content
. Author manuscript; available in PMC: 2014 May 15.
Published in final edited form as: Periodontol 2000. 2013 Oct;63(1):149–164. doi: 10.1111/prd.12034

Table 1. Resolution of lipid mediator cellular actions.

Lipid mediator Cellular function References
Lipoxin A4 / aspirin-triggered lipoxin Decreases adherence of leukocytes Papayianni et al. (71)
Reduces vascular leakage Takano et al. (98)
Lowers prostaglandin E2 levels in exudates Pouliot et al. (73)
Reduces the number of apoptotic neutrophils Perretti et al. (72)
Inhibits neutrophil recruitment Serhan et al. (90)
Attenuates expression of the nuclear factor-kappaB gene Chiang et al. (20)
Blocks leukocyte adhesion protein-1 and chemotaxis Ohira et al. (70)
Promotes lymphatic removal of phagocytes Bannenberg et al. (13)
Activates FLRP2/Lipoxin A4 receptor receptor internalization and phagocytosis Maderna et al. (59)
Inhibits T-cell adhesion to vascular and salivary epithelium Chintamani et al. (21)
Enhances microbial phagocytic function Tobin et al. (100)
Resolvin E1 Inhibits neutrophil infiltration Serhan et al. (86)
Modulates chemokine/cytokine synthesis Bannenberg et al. (13)
Promotes healing of inflamed tissues and bone regeneration Hasturk et al. (39)
Enhances phagocytosis Schwab et al. (80)
Activates lymphatic removal of phagocytes Van Dyke et al. (101)
Attenuates systemic production of C-reactive protein and interleukin-1 Hasturk et al. (38)
Reduces eosinophil and lymphocyte recruitment Aoki et al. (5)
Regulates adipokines Gonzalez-Periz et al. (35)
Decreases inflammatory actions of cyclooxygenase-2 Li et al. (56)
Attenuate expression of the nuclear factor-kappaB gene Ishida et al. (46)
Lowers the number of monocytes Li et al. (56)
Increases CD55 expression on epithelial cells and polymorphonuclear cell clearance Campbell et al. (18)
Rescues impaired phagocytosis in LAP patient macrophages Freedman et al. (30)
Prevents rejection of allograft Levy et al. (55)
Activates anti-apoptotic signals El Kebir et al. (27)
Resolvin D1 Inhibits neutrophil recruitment Serhan et al. (89)
Anti-hyperalgesic properties Albert et al. (2)
Shortens resolution interval Hong et al. (43)
Reduces oxidative stress-mediated inflammation Spite et al. (97)
Attenuates agonist pain molecules Bang et al. (12)
Induces macrophage phagocytosis Krishnamoorthy et al. (52)
Stimulates the M2 macrophage phenotype Titos et al. (99)
Temporally regulates microRNAs Recchiuti et al. (75)
Reduces cytokines in bronchoalveolar lavage fluid Wang et al. (105)
Ameliorates insulin sensitivity Hellman et al. (40)
Enhances microbial clearance Chiang et al. (19)
Reduces levels of prostaglandins and leukotrienes Norling et al. (67)
Protectin D1/AT-PD1 Decreases inflammatory actions of cyclooxygenase-2 Marcheselli et al. (63)
Inhibits neutrophil infiltration Bannenberg et al. (13)
Modulates chemokine/cytokine synthesis Serhan et al. (88)
Regulates T-cell migration Ariel et al. (6)
Regulates macrophage function Duffield et al. (25)
Up-regulates CCR5 expression on apoptotic leukocytes Schwab et al. (80)
Prevents hepatocyte steatosis Gonzalez-Periz et al. (35)
Inhibits pain signals Bang et al. (12)
Suppresses eosinophil chemotaxis and adhesion Miyata et al. (65)
Maresin -1 Reduces neutrophil numbers in exudate Serhan et al. (93)
Enhances macrophage phagocytic functions Serhan et al. (87)
Decreases transendothelial polymorphonuclear cell migration Shinohara et al. (95)