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. 2014 Apr 30;2014:230346. doi: 10.1155/2014/230346

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Copyright © 2014 Florent Montespan et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Both BM- andAT-derived MSCs when combined to MBCP biomaterial keep their hypoimmunogenicity. PBMC from healthy individual (#713) were used as responder cells towards either BM-derived MSCs (MSC-BM) or AT-derived MSCs (MSC-AT) that were pretreated with IFNγ and TNFα (IFNγ/TNFα) or not and used as stimulating cells at the responder : stimulator ratio of 1 : 0.2. MSCs were combined to MBCP biomaterial (MBCP) or not (No MBCP). Irradiated LCL* were used as positive control of T cell alloproliferation. Results are given as mean cpm ± s.e.m.; one representative experiment is shown.