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. 2014 Apr 30;2014:230346. doi: 10.1155/2014/230346

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Copyright © 2014 Florent Montespan et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Both BM- andAT-derived MSCs display immunosuppressive properties in a dose-dependent manner. PBMC from healthy individuals were used as responder cells towards irradiated LCL* used as stimulating cells in presence of either (a) BM-derived MSCs (MSC-BM) or (b) AT-derived MSCs (MSC-AT) that were pretreated with IFNγ and TNFα (IFNγ/TNFα) or not and used as third-party cells at various responder : stimulator : MSC ratios. Results are given as mean percentage of alloproliferation inhibition ± s.e.m. according to the maximal alloproliferation observed with PBMC+LCL* using PBMC from 4 and 6 distinct healthy donors in BM- and AT-derived MSCs experiments, respectively.