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. 2014 Apr 30;2014:230346. doi: 10.1155/2014/230346

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Copyright © 2014 Florent Montespan et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Both BM- andAT-derived MSCs when combined to MBCP biomaterial keep their immunosuppressive properties. PBMC from healthy individuals were used as responder cells towards irradiated LCL* used as stimulating cells in presence of either BM-derived MSCs (MSC-BM) or AT-derived MSCs (MSC-AT) that were pretreated with IFNγ and TNFα (IFNγ/TNFα) or not and used as third-party cells at various responder : stimulator : MSC ratios. MSCs were combined to MBCP biomaterial (MBCP) or not (No MBCP). Results are given as mean percentage of alloproliferation inhibition ± s.e.m. when compared to PBMC+LCL* using PBMC from 3 distinct healthy donors.