Table 2.
Anaemia and iron status according to iron diet, DOX treatment, and supplementation with FCM.
| Group | ||||||||
|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | |
| Treatment | ||||||||
| Iron diet | LID | LID | LID | LID | LID | LID | ND | ND |
| DOX (4 mg/kg BW) | + | + | + | + | + | − | − | + |
| FCM (mg iron/kg BW) | 3 | 3 | 15 | 15 | − | − | − | 15 |
| Concurrent with DOX | Three days after DOX | Concurrent with DOX | Three days after DOX | Concurrent with DOX | ||||
| Saline | − | − | − | − | + | + | + | − |
| Parameter | ||||||||
| Hb (g/dL) | 14.5 ± 0.5‡ | 14.6 ± 0.3‡ | 15.6 ± 0.4 | 15.5 ± 0.6 | 10.3 ± 0.3†§ | 11.0 ± 0.3† | 17.2 ± 0.7* | 17.0 ± 0.7* |
| Serum iron (μg/dL) | 214.3 ± 17.7 | 218.7 ± 15.8 | 221.8 ± 16.0 | 223.6 ± 15.0 | 117.1 ± 14.0† | 121.0 ± 15.4 | 248.6 ± 16.6∗|| | 320.4 ± 19.5∗¶ |
| TSAT (%) | 36.2 ± 2.1 | 36.3 ± 2.3 | 36.2 ± 2.0 | 36.4 ± 2.1 | 19.2 ± 3.1† | 20.0 ± 3.2 | 41.3 ± 2.1∗|| | 47.8 ± 2.4∗¶ |
| L-Ferritin (%/area) | 10.3 ± 1.6 | 10.5 ± 1.0 | 10.4 ± 1.1 | 10.7 ± 1.4 | 1.8 ± 0.4† | 1.6 ± 0.3† | 3.1 ± 0.5* | 15.7 ± 1.9* |
Data presented as mean ± SD. LID: low iron diet; ND: normal diet; DOX: doxorubicin; FCM: ferric carboxymaltose; Hb: hemoglobin; TSAT: transferrin saturation.
*P < 0.05 for G7 and G8 versus G1, G2, G3, G4, G5, and G6; † P < 0.01 for G5 and G6 versus G1, G2, G3, and G4; ‡ P < 0.05 for G1 and G2 versus G3 and G4; § P < 0.01 for G5 versus G6; || P < 0.05 for G7 versus G1, G2, G3, and G4; ¶ P < 0.01 for G8 versus G1, G2, G3, G4, and G7.