Table 3.
Echocardiographic outcomes according to iron diet, DOX treatment, and supplementation with FCM.
| Group | ||||||||
|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | |
| Parameter | ||||||||
| LVDD (mm) | 8.00 ± 0.09§ | 8.01 ± 0.09§ | 7.91 ± 0.10§§ | 7.90 ± 0.10§§ | 8.55 ± 0.11‡ | 8.17 ± 0.08† | 7.81 ± 0.10|| | 8.58 ± 0.11 |
| LVSD (mm) | 5.01 ± 0.08* | 5.00 ± 0.09* | 4.85 ± 0.09§ | 4.80 ± 0.10§ | 5.80 ± 0.10** | 5.25 ± 0.08† | 4.31 ± 0.11|| | 6.00 ± 0.10 |
| LVPW (mm) | 2.36 ± 0.10 | 2.33 ± 0.12 | 2.34 ± 0.11 | 2.33 ± 0.10 | 2.39 ± 0.12 | 2.36 ± 0.11 | 2.30 ± 0.12 | 2.29 ± 0.10 |
| IVS (mm) | 2.36 ± 0.10 | 2.36 ± 0.11 | 2.36 ± 0.09 | 2.36 ± 0.10 | 2.46 ± 0.11 | 2.39 ± 0.11 | 2.31 ± 0.10 | 2.30 ± 0.10 |
| FS (%) | 37.4 ± 0.5|||| | 37.6 ± 0.5|||| | 38.7 ± 0.6§ | 39.2 ± 0.9§ | 32.2 ± 1.0** | 35.7 ± 0.6† | 44.8 ± 1.1|| | 30.1 ± 1.3 |
| LVM (g) | 1.33 ± 0.06¶ | 1.31 ± 0.07‡‡ | 1.28 ± 0.09‡‡ | 1.25 ± 0.08‡‡ | 1.48 ± 0.06** | 1.36 ± 0.06†† | 1.20 ± 0.07|| | 1.32 ± 0.08 |
Data presented as mean ± SD. A brief tabular overview of treatments in Groups 1–8 is included in Table 2. Further details are described in the Materials and Methods section. LID: low iron diet; ND: normal diet; DOX: doxorubicin; FCM: ferric carboxymaltose; LVDD: left ventricular end-diastolic diameter; LVSD: left ventricular end-systolic diameter; LVPW: left ventricular posterior wall thickness; IVS: interventricular septum thickness; FS: fractional shortening; LVM: left ventricular mass.
*P < 0.01 versus G3 to G8; † P < 0.01 versus G7 and G8; ‡ P < 0.01 versus G6 and G7; § P < 0.01 versus G5 to G8; || P < 0.01 versus G8; ¶ P < 0.01 versus G5 and G7; **P < 0.01 versus G6 to G8; †† P < 0.01 versus G7; ‡‡ P < 0.01 versus G5; §§ P < 0.01 versus G5, G6, and G8; |||| P < 0.01 versus G4 to G8.