Table 2.
Summary of the included studies.
| Study/country | RCC subtype | Total number of cases | Median age (years) | Cases with followup assessed for 9p status |
cN+M+ n= (%) |
Median follow-up months | Follow-up protocol described |
Primary outcome analysed |
5-year survival | P value | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 9p deleted | 9p retained | ||||||||||
| (1) Antonelli et al., 2010 [31] ITA | ccRCC | 131 | 62.9 (mean) |
131 | 19 (14.5%) |
73 | Yes | CSS | 60% | 78% | 0.312 |
|
| |||||||||||
| (2) Brunelli et al.,2008 [32] ITA | ccRCC | 73 | 65 | 73 | 7 (10%) |
45 | No | CSS | 43% | 88% | <0.001* |
|
| |||||||||||
| (3) Gunawan et al., 2003 [33] GER | pRCC | 50 | 62 | 38 | 9 (24%) |
41 | No | DFS | NS | NS | 0.00003 |
|
| |||||||||||
| (4) Klatte et al., 2009 [34] USA | pRCC | 65 | 61 | 57 | NS | 39 | No | CSS | 0% | 80% | 0.009* |
|
| |||||||||||
| (5) La Rochelle et al., 2010 [29] USA | ccRCC | 703 | NS | 703 | 260 (37%) |
Mean 40 | Yes | DFS CSS (only N0M0) |
49% 67% |
77% 87% |
<0.001* <0.014* |
|
| |||||||||||
| (6) Li et al., 2011 [35] CHINA | ccRCC | 93 | 55.5 | 78 | 0% | 31.7 | Yes | DFS (LOH) CSS (LOH) |
26% 28% |
98% 98% |
0.001 0.001* |
|
| |||||||||||
| (7) Moch et al. 1996 [36] SWI | ccRCC | 41 (pT3) | NS | 37 | 0% | 39 | Yes | DFS | 31% | 70% | 0.04 |
|
| |||||||||||
| (8) Presti et al., 2002 [37] USA | ccRCC | 72 (pT3) | NS | 67 | 0% | 41 | No | DFS | 50% | 71% | 0.14 |
|
| |||||||||||
| (9) Sanjmyatav et al., 2011 [38] GER | ccRCC | 53 | 61 | 53 | 31 (58%) |
47 | No | CSS | 0% | 75% | 0.00001 |
|
| |||||||||||
| (10) Schaml et al., 2001 [39] SWI | ccRCC | 113 | NS | 88 | 12 (14%) |
48 | No | CSS (only pT3) (n = 37) | LOH 0% | 58% | 0.01 |
|
| |||||||||||
| (11) Schraml et al., 2000 [40] SWI | pRCC | 37 | NS | 21 | NS | 54 | No | OS | 40% | 81% | 0.008* |
ccRCC: clear cell renal cell carcinoma; pRCC: papillary renal cell carcinoma; NS: not stated clearly; CSS: cancer specific survival; DFS: disease free survival; OS: overall survival; LOH: loss of heterozygosity; *Statistically significant on multivariate analysis.