Table 2.
Clinical results of 1420 CCS cycles according to the different indications.
| RM <40 yrs | RIF <40 yrs | PTP <40 yrs | MF <40 yrs | AMA ≥40 yrs | |
|---|---|---|---|---|---|
| Number of cycles | 203 | 188 | 33 | 116 | 880 |
| Mean female age (SD) | 35.9 (2.7) | 36.5 (2.5) | 36.8 (2.4) | 34.8 (3.2) | 41.5 (2.1) |
| Mean number of embryos analyzed (SD) | 5.5 (3.1)b,d,e | 5.9 (3.0)a,d,e | 5.7 (3.8)d,e | 6.8 (3.7)a,b,c,e | 4.6 (2.6)a,b,c,d |
| Number of informative embryos | 1099 | 1064 | 186 | 797 | 3972 |
| Total number of aneuploid embryos (%) | 750 (68.2)e | 720 (67.7)e | 133 (71.5)e | 521 (65.4)e | 3403 (85.3)a,b,c,d |
| Number of segmental aneuploidies (%) | 61 (5.5)e | 40 (3.7)c | 19 (10.2)b,d,e | 32 (4.0)c | 126 (3.2)a,c |
| Number of embryos with a chaotic pattern (%) | 180 (16.4)b | 119 (11.2)a,e | 24 (12.9) | 125 (15.5) | 620 (15.6)b |
| Number of embryos with >1 aneuploidy (%) | 237 (21.6)e | 250 (23.5)e | 41 (22.0)e | 158 (19.8)e | 1711 (43.1)a,b,c,d |
| Number of embryo transfers (%) | 157 (77.3)e | 149 (79.2)e | 26 (78.8)e | 97 (83.6)e | 354 (40.3)a,b,c,d |
| Mean transferred embryos (SD) | 1.5 (0.5) | 1.5 (0.6) | 1.4 (0.5) | 1.5 (0.5) | 1.3 (0.5) |
| Number of pregnancies/transfer (%) | 90 (57.3) | 85 (57.0) | 12 (46.0) | 61 (62.9) | 170 (48.0) |
| Number of pregnancies/cycle (%) | 90 (44.3)e | 85 (45.2)e | 12 (36.4) | 61 (52.1)e | 170 (19.3)a,b,d |
| Implantation rate | 47.9 | 50.9 | 40.5 | 54.2 | 42.4 |
| Miscarriage rate | 13.3 | 4.7 | 16.7 | 3.3 | 6.5 |
| Delivery rate/cycle | 38.4 (78)e | 43.1 (81)e | 30.3 (10) | 50.9 (59)e | 18.1 (159)a,b,d |
RM: recurrent miscarriage; RIF: repetitive implantation failure; MF: severe male factor; PTP: previous trisomic pregnancy; AMA: advanced maternal age.
a P < 0.05 versus RM <40 yrs; b P < 0.05 versus RIF <40 yrs; c P < 0.05 versus PTP <40 yrs; d P < 0.05 versus MF <40 yrs; e P < 0.05 versus AMA ≥40 yrs. Chi-square test, Fisher exact test, or Welch t-test with Bonferroni's correction.