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(a) Glioma initiating cells seem to be radioresistant and chemoresistant to conventional therapies and, eventually, this results in tumor recurrence. (b) One approach to target GICs in GBM could be to develop a specific chemotherapeutic agent (such as BMPs or newly synthesized molecules mimicking BMPs) able to induce GICs to differentiate into cells more amenable to standard therapy. The expression of BMPRIB would be key for inducing differentiation of GICs.
