Table 2.
Disease-related enrichment analysis of H. sapiens proteins involved in host-pathogen PPIs
| Gene list | Overlap | p-value |
|---|---|---|
|
(a) | ||
| Early Changers |
32 |
1.022E-10 |
| Late Changers |
31 |
3.785E-14 |
| Consistent Changers |
35 |
1.500E-14 |
| Early and Late Changers |
56 |
6.996E-21 |
| Early and Consistent Changers |
49 |
3.721E-18 |
| Consistent and Late Changers |
42 |
1.499E-16 |
| Macrophages and dendritic differentially expressed genes |
107 |
2.097E-34 |
|
(b) | ||
| Early Changers |
6 |
3.08E-02 |
| Late Changers |
6 |
6.11E-03 |
| Consistent Changers |
8 |
1.04E-03 |
| Early and Late Changers |
10 |
2.94E-03 |
| Early and Consistent Changers |
9 |
4.30E-03 |
| Consistent and Late Changers |
9 |
1.07E-03 |
| Macrophages and dendritic differentially expressed genes | 35 | 5.23E-14 |
This table summarizes H. sapiens proteins’ (involved in the predicted host-pathogen PPIs) enrichment (over-representation) in M. tuberculosis H37Rv infection and treatment-related differentially expressed gene lists.
(a) is enrichment analysis results from the stringent homology-based approach.
(b) is enrichment analysis results from the conventional homology-based approach.