Table 4.
Pathway enrichment analysis of H. sapiens proteins involved in the predicted host-pathogen PPI dataset
| Pathway names | p-value |
|---|---|
|
(a) | |
| Focal adhesion |
5.85E-13 |
| Translation factors |
6.61E-12 |
| Pathways in cancer |
7.51E-12 |
| Measles |
5.21E-09 |
| Pancreatic cancer |
7.44E-09 |
| Proteasome |
8.80E-09 |
| Antigen processing and presentation |
1.68E-08 |
| Adipogenesis |
3.41E-08 |
| Myometrial relaxation and contraction pathways |
5.66E-08 |
| MAPK signaling pathway |
5.82E-08 |
| Endocytosis |
5.87E-08 |
| Integrated cancer pathway |
5.89E-08 |
| Viral myocarditis |
8.03E-08 |
| Cell cycle |
8.28E-08 |
| Leishmaniasis |
1.08E-07 |
| T cell receptor signaling pathway |
1.12E-07 |
| Tuberculosis |
2.76E-07 |
| Spliceosome |
7.79E-07 |
| Renal cell carcinoma |
7.82E-07 |
| Amoebiasis |
8.28E-07 |
| (b) | |
| Hepatitis C |
2.03E-14 |
| Pathways in cancer |
2.52E-13 |
| Endocytosis |
3.20E-13 |
| MAPK signaling pathway |
5.66E-13 |
| Neurotrophin signaling pathway |
4.67E-12 |
| v Cell cycle |
1.78E-11 |
| Shigellosis |
4.18E-11 |
| T cell receptor signaling pathway |
3.21E-10 |
| Senescence and autophagy |
7.20E-10 |
| NOD-like receptor signaling pathway |
9.06E-10 |
| Prostate cancer |
1.35E-09 |
| EBV LMP1 signaling |
4.64E-09 |
| RIG-I-like receptor signaling pathway |
4.74E-09 |
| Acute myeloid leukemia |
2.42E-08 |
| Osteoclast differentiation |
3.37E-08 |
| Apoptosis |
3.86E-08 |
| Chagas disease (American trypanosomiasis) |
9.86E-08 |
| Pancreatic cancer |
1.03E-07 |
| Proteasome |
1.14E-07 |
| DNA damage response | 1.25E-07 |
(a) summarizes the 20 most significantly enriched pathways for H. sapiens proteins involved in the host-pathogen PPI dataset predicted by our stringent homology-based approach.
(b) summarizes the 20 most significantly enriched pathways for H. sapiens proteins involved in the host-pathogen PPI dataset predicted by the conventional homology-based approach.