Table 4.
Relationship between Volume and Dementia Questionnaire for People with Learning Disabilities (DLD) sum of cognitive scores (SCS) and sum of social scores (SOS) or APOE in brain regions showing a correlation with age in Down syndrome participants
| Region of interest |
DLD-SCS |
DLD-SOS |
APOE
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| t | P -value | Difference in R 2 | t | P -value | Difference in R 2 | t | P -value | Difference in R 2 | |
| LILV |
2.37 |
0.042 |
0.21 |
4.72 |
0.001 |
0.38 |
2.61 |
0.026 |
0.22 |
| RILV |
2.56 |
0.031 |
0.25 |
4.01 |
0.003 |
0.38 |
2.47 |
0.033 |
0.22 |
| Left superior parietal |
-1.32 |
0.219 |
0.06 |
0.41 |
0.693 |
0.01 |
-1.06 |
0.315 |
0.04 |
| Left pars orbitalis |
-1.66 |
0.131 |
0.08 |
-1.32 |
0.220 |
0.06 |
-1.23 |
0.247 |
0.10 |
| Left inferior parietal |
-1.21 |
0.256 |
0.07 |
-1.59 |
0.146 |
0.10 |
-1.87 |
0.091 |
0.06 |
| Right post central gyrus |
-0.54 |
0.604 |
0.01 |
-1.11 |
0.294 |
0.05 |
0.05 |
0.961 |
0.00 |
| Left ventricle |
0.57 |
0.582 |
0.01 |
2.06 |
0.069 |
0.13 |
1.45 |
0.178 |
0.07 |
| Right ventricle | 0.91 | 0.386 | 0.03 | 2.59 | 0.029 | 0.15 | 1.78 | 0.105 | 0.08 |
Italicized P-values indicate nominal association at uncorrected P < .05. The Difference in R2 values indicates the difference in the variability in the region of interest (ROI) volume explained by the full model that included the predictor of interest (DLD-SCS, DLD-SOS, or APOE), compared to that explained by the reduced model with only age and sex as predictors.