Table 2.
In vivo heart functional parameters of rats by echocardiography at 4 weeks
| Heart function |
Sham group |
MI group |
CoPP-MI group |
CoPP + SnMP MI group |
|---|---|---|---|---|
| n = 20 | n = 35 | n = 25 | n = 6 | |
| LVEDd (mm) |
5.5 ± 0.2 |
7.4 ± 0.4**# |
6.3 ± 0.3* |
8.5 ± 0.4**# |
| LVESd (mm) |
2.0 ± 0.2 |
5.0 ± 0.3**# |
2.9 ± 0.1 |
6.0 ± 0.4**# |
| EDAW (mm) |
1.6 ± 0.1 |
1.1 ± 0.1**# |
1.5 ± 0.1 |
1.1 ± 0.1**# |
| EDPW (mm) |
1.6 ± 0.1 |
1.9 ± 0.1**# |
1.6 ± 0.1 |
1.9 ± 0.7**# |
| SAWT% |
71 ± 3 |
35 ± 2**# |
60 ± 3* |
38 ± 5**# |
| SPWT% |
70 ± 2 |
41 ± 2**# |
69 ± 2 |
52 ± 4**# |
| FS% |
65 ± 3 |
34 ± 2**# |
54 ± 2* |
29 ± 3**# |
| HR | 456 ± 7 | 495 ± 5**# | 443 ± 6 | 470 ± 9# |
Values are mean ± SEM; n, number of animals tested; LVEDd, left ventricular end-diastole diameter; LVESd, left ventricular end-systole diameter; EDAW, end-diastole anterior wall thickness; EDPW, end-diastole posterior (remote) wall thickness; SAWT%, percent systolic anterior wall thickening; SPWT%, percent systolic posterior (remote) wall thickening; FS%. percent fractional shortening. HR, heart rate. *p < 0.05 and **p < 0.001 vs sham-operated; #p < 0.001 vs CoPP-treated infarct.