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. Author manuscript; available in PMC: 2014 May 15.
Published in final edited form as: Nature. 2012 Nov 28;493(7431):236–240. doi: 10.1038/nature11674

Figure 1. COUP-TFII is crucial for prostate cancer progression in human and mice.

Figure 1

a, Expression and clinical relevance of COUP-TFII are assessed in a human prostate cancer TMA. COUP-TFII staining indexes in cohorts of normal prostate epithelial cells (n = 407) and prostate tumours (n = 416) are shown as stacked columns. b, Kaplan–Meier plot of the recurrence after radical prostatectomy based on the COUP-TFII expression index in patients. HR, hazard ratio. c, Haematoxylin and eosin (H&E) staining of the anterior prostate from PtenPC–/– and PtenPC–/–; COUP-TFIIPC–/– mice at 5 months of age. Scale bar, 50 μm. d, Pie graphs show prostate tumour progressions in PtenPC–/– and PtenPC–/–; COUP-TFIIPC–/– mice (5 months old; n = 10). HGPIN, high-grade PIN; LGPIN, low-grade PIN.