Table 1.
Study | Injury model | Species | Sex | Methods | Cell type antibodies | M1 markers | M2 markers |
---|---|---|---|---|---|---|---|
Bedi et al. [40] |
CCI |
Mouse |
Male |
FC |
CD11b, CD45 |
CD16/CD32 |
CD206 |
Hsieh et al. [34] |
CCI |
Mouse |
Male |
FC, qRT-PCR on FC-sorted cells |
CD11b, CD45, F4/F80, Ly6G |
CD86, MHC II, YFP-IL-12p40 |
YFP-Arg1 |
Kigerl et al. [9] |
SCI |
Mouse |
Not specified |
IHC, qRT-PCR |
None |
CD16/CD32, CD86, iNOS, MHC II |
Arg1, CD206 |
Kumar et al. [15] |
CCI |
Mouse |
Male |
IHC, qRT-PCR |
CD11b, CD68, Iba1 |
MHC II |
Ym1 |
Lagraoui et al. [32] |
CCI |
Mouse |
Male |
qRT-PCR, multiplex |
None |
None |
None |
Present study |
CCI |
Rat |
Female |
FC, IHC, qRT-PCR, multiplex |
CD68, Iba1 |
CD40, CD86 |
CD163 |
Wang et al. [35] |
CCI |
Mouse |
Male |
IHC, qRT-PCR |
Iba1 |
CD16/CD32 |
CD206 |
Zhang et al. [36] | CCI | Rat | Not specified | IHC | CD68 | None | CD163 |
aArg1, Arginine 1; CCI, Controlled cortical impact; FC = Flow cytometry; Iba1, Ionized calcium-binding adapter molecule 1; IHC, Immunohistochemistry; IL, Interleukin; iNOS, Inducible nitric oxide synthase; MHC II, Major histocompatibility complex class II; qRT-PCR, Quantitative RT-PCR; SCI = Spinal cord injury, YFP = Yellow fluorescent protein.