Table 4.
HR (95% CI) and estimated loss of RLE (95% CI) for body weight status, after exclusion of early deaths, and after stratification by smoking status, the EPIC-Heidelberg cohort a
| |
Men |
|
Women |
||
|---|---|---|---|---|---|
| Multivariable HR (95% CI) | Loss of RLE (95% CI) | Multivariable HR (95% CI) | Loss of RLE (95% CI) | ||
| Early deathsb excluded |
|
|
|
|
|
| Body weight status |
|
|
|
|
|
| Optimal BMI |
1.00 |
0 |
1.00 |
0 |
|
| Low BMI |
1.51 (1.15, 1.98) |
3.0 (1.0, 4.6) |
1.30 (1.00, 1.69) |
1.8 (0.3, 3.1) |
|
| Overweight |
1.14 (0.95, 1.37) |
1.0 (0, 2.0) |
1.02 (0.79, 1.30) |
0.1 (−1.1, 1.7)c |
|
| Obesity |
1.49 (1.21, 1.84) |
2.9 (1.8, 4.1) |
1.48 (1.13, 1.93) |
2.6 (1.2, 4.3) |
|
| Stratified by smoking status |
|
|
|
|
|
| Never smokers |
|
|
|
|
|
| Optimal BMI |
1.00 |
0 |
1.00 |
0 |
|
| Low BMI |
1.50 (0.80, 2.82) |
2.9 (−2.5, 6.4)c |
1.05 (0.71, 1.55) |
0.4 (−2.4, 2.8)c |
|
| Overweight |
1.15 (0.77, 1.72) |
1.0 (−1.5, 3.7)c |
0.97 (0.69, 1.36) |
−0.2 (−2.0, 2.1)c |
|
| Obesity |
2.05 (1.31, 3.21) |
5.2 (2.1, 8.6) |
1.53 (1.06, 2.19) |
3.0 (0.9, 5.2) |
|
| Former smokers |
|
|
|
|
|
| Optimal BMI |
100 |
0 |
1.00 |
0 |
|
| Low BMI |
1.32 (0.77, 2.29) |
2.0 (−1.6, 5.4)c |
1.14 (0.63, 2.08) |
0.9 (−3.1, 4.4)c |
|
| Overweight |
1.36 (1.01, 1.83) |
2.2 (0.6, 4.4) |
1.41 (0.86, 2.32) |
2.3 (−0.6, 5.2)c |
|
| Obesity |
1.55 (1.10, 2.18) |
3.1 (1.2, 5.4) |
1.37 (0.75, 2.48) |
2.1 (−1.1, 5.6)c |
|
| Current smokers |
|
|
|
|
|
| Optimal BMI |
1.00 |
0 |
1.00 |
0 |
|
| Low BMI |
1.70 (1.21, 2.40) |
4.3 (1.7, 6.6) |
1.83 (1.19, 2.82) |
4.8 (2.1, 8.0) |
|
| Overweight |
1.00 (0.77, 1.31) |
0 (−1.9, 2.0)c |
1.04 (0.66, 1.63) |
0.3 (−2.6, 3.4)c |
|
| Obesity | 1.39 (1.00,1.92) | 2.7 (0.6, 5.2) | 1.68 (1.01, 2.80) | 4.2 (0.6, 7.6) | |
aParticipants with pre-existing diabetes, cardiovascular disease or cancer were excluded. bDeaths occurred in the first two years of the follow-up period (nmen = 48; nwomen = 33). cMinus sign denotes a gain in RLE. BMI, body mass index; CI, confidence interval; EPIC, European Prospective Investigation into Cancer and Nutrition; HR, hazard ratio; RLE, residual life expectancy.