Table 1.
GSEA analysis: gene sets significantly correlated with MAT-inducing treatments
| Biological category | Gene set | Size | NES | FDR (q-value) | Enriched in |
|---|---|---|---|---|---|
| EGF signalling |
NAGASHIMA_EGF_SIGNALING_UP |
57 |
2.773 |
0.000 |
Treated |
| NAGASHIMA_NRG1_SIGNALING_UP |
169 |
2.826 |
0.000 |
Treated |
|
| ZWANG_CLASS1_TRANSIENTLY_INDUCED_BY_EGF |
497 |
2.455 |
0.000 |
Treated |
|
| AMIT_EGF_RESPONSE_60_HELA |
43 |
2.305 |
0.000 |
Treated |
|
| ZWANG_CLASS3_TRANSIENTLY_INDUCED_BY_EGF |
217 |
2.263 |
0.000 |
Treated |
|
| AMIT_EGF_RESPONSE_240_HELA |
59 |
2.177 |
0.001 |
Treated |
|
| AMIT_EGF_RESPONSE_120_HELA |
67 |
2.098 |
0.002 |
Treated |
|
| AMIT_EGF_RESPONSE_480_MCF10A |
42 |
2.034 |
0.004 |
Treated |
|
| AMIT_EGF_RESPONSE_40_HELA |
42 |
1.972 |
0.007 |
Treated |
|
| Epithelial-mesenchymal transition |
ANASTASSIOU_CANCER_MESENCHYMAL_TRANSITION_SIGNATURE |
63 |
-2.348 |
0.000 |
Control |
| AIGNER_ZEB1_TARGETS |
34 |
-2.148 |
0.002 |
Control |
|
| ONDER_CDH1_TARGETS_1_DN |
166 |
2.339 |
0.000 |
Treated |
|
| KARLSSON_TGFB1_TARGETS_UP |
124 |
2.426 |
0.000 |
Treated |
|
| PLASARI_TGFB1_TARGETS_1HR_UP |
34 |
2.296 |
0.000 |
Treated |
|
| Extracellular matrix |
REACTOME_COLLAGEN_FORMATION |
57 |
-2.547 |
0.000 |
Control |
| PROTEINACEOUS_EXTRACELLULAR_MATRIX |
95 |
-2.224 |
0.001 |
Control |
|
| KEGG_ECM_RECEPTOR_INTERACTION |
84 |
-2.264 |
0.001 |
Control |
|
| PID_INTEGRIN1_PATHWAY |
66 |
-2.200 |
0.001 |
Control |
|
| EXTRACELLULAR_MATRIX_PART |
54 |
-2.203 |
0.001 |
Control |
|
| KEGG_CELL_ADHESION_MOLECULES_CAMS |
130 |
-2.127 |
0.002 |
Control |
|
| EXTRACELLULAR_MATRIX |
96 |
-2.108 |
0.002 |
Control |
|
| REACTOME_EXTRACELL_MATRIX_ORGANIZATION |
83 |
-2.063 |
0.004 |
Control |
|
| COLLAGEN |
22 |
-1.994 |
0.007 |
Control |
|
| HOXA5 pathway |
CHEN_HOXA5_TARGETS_9HR_UP |
216 |
3.745 |
0.000 |
Treated |
| HDAC |
SENESE_HDAC1_AND_HDAC2_TARGETS_UP |
227 |
2.790 |
0.000 |
Treated |
| SENESE_HDAC1_TARGETS_UP |
429 |
2.968 |
0.000 |
Treated |
|
| SENESE_HDAC2_TARGETS_UP |
110 |
2.525 |
0.000 |
Treated |
|
| SENESE_HDAC3_TARGETS_UP |
471 |
2.281 |
0.000 |
Treated |
|
| Stemness |
NGUYEN_NOTCH1_TARGETS_DN |
85 |
2.258 |
0.000 |
Treated |
| RAMALHO_STEMNESS_UP |
201 |
2.089 |
0.002 |
Treated |
|
| Rho metabolic process |
BERENJENO_TRANSFORMED_BY_RHOA_DN |
381 |
-1.951 |
0.010 |
Control |
| CELLULAR_PROTEIN_CATABOLIC_PROCESS |
56 |
2.164 |
0.001 |
Treated |
|
| REACTOME_DEADENYLATION_OF_MRNA |
19 |
2.062 |
0.003 |
Treated |
|
| PROTEIN_CATABOLIC_PROCESS |
64 |
2.058 |
0.003 |
Treated |
|
| MRNA_METABOLIC_PROCESS |
83 |
1.940 |
0.009 |
Treated |
|
| OXIDOREDUCTASE_ACTIVITY |
281 |
-2.123 |
0.002 |
Control |
|
| OXIDOREDUCTASE_ACTIVITY_GO_0016616 |
56 |
-1.991 |
0.007 |
Control |
|
| OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS |
62 |
-1.951 |
0.010 |
Control |
|
| Metastasis |
CHANDRAN_METASTASIS_UP |
197 |
1.975 |
0.007 |
Treated |
| |
CHANDRAN_METASTASIS_TOP50_UP |
37 |
1.967 |
0.007 |
Treated |
| PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_1 | 45 | 2.300 | 0.000 | Treated |