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. 2014 Apr 24;7:66. doi: 10.1186/1754-6834-7-66

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Copyright © 2014 Kunze et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Scheme of the key components of the purine degradation pathway. The image shows the reversible (double headed arrow) and irreversible (single headed arrow) reactions catalyzed by the corresponding enzymes (rectangular square) for purine degradation. The colors represent up regulation (red) and down regulation (blue) of genes in cells shifted to medium containing adenine as the sole nitrogen source compared to cells grown with nitrate. Black marked symbols indicate intermediates occurring several times in the pathway. Fold change (FC) values of gene expression are given within the colored boxes.