Table 2.
HbA 1c level and platelet morphology in the participants according to diabetic state and PLA1A2 polymorphism
| |
Values |
Logistic regression |
|
|
|---|---|---|---|---|
| All (N = 4,028) | A1A1 (mean ± SD) | AxA2 (mean ± SD) | Odds ratio (95% CI) | P |
| HbA1c [%] |
5.56 ± 0.58 |
5.60 ± 0.71 |
1.03 (0.96, 1.11) |
0.42 |
| HbA1c [mmol/mol] |
37.3 ± 6.3 |
37.7 ± 7.8 |
|
|
| MPV [fl] |
8.76 ± 0.96 |
8.66 ± 0.89 |
0.90 (0.83, 0.96) |
0.003 |
| Platelet mass |
2,100 · 2 ± 454.4 |
2,090.4 ± 460.8 |
0.99 (0.92, 1.07) |
0.75 |
| Platelet count [nl] |
242.7 ± 58.3 |
243.9 ± 57.4 |
1.03 (0.96, 1.12) |
0.33 |
|
Diabetes (N = 209) |
|
|
|
|
| HbA1c [%] |
7.04 ± 1.41 |
7.63 ± 1.64 |
1.19 (1.04, 1.35) |
0.01 |
| HbA1c [mmol/mol] |
53.4 ± 15.4 |
68.9 ± 8.9 |
|
|
| MPV [fl] |
9.02 ± 1.07 |
8.97 ± 0.96 |
1.03 (0.76, 1.38) |
0.86 |
| Platelet mass |
1,996.80 ± 516.49 |
1,979.13 ± 420.85 |
0.93 (0.67, 1.30) |
0.70 |
| Platelet count [nl] |
224.97 ± 65.86 |
223.20 ± 52.06 |
0.91 (0.66, 1.25) |
0.57 |
|
Non-Diabetes (N = 3,819) |
|
|
|
|
| HbA1c [%] |
5.48 ± 0.35 |
5.48 ± 0.36 |
0.97 (0.85, 1.11) |
0.69 |
| HbA1c [mmol/mol] |
36.4 ± 3.8 |
36.4 ± 3.9 |
|
|
| MPV [fl] |
8.74 ± 0.95 |
8.64 ± 0.89 |
0.89 (0.83, 0.96) |
0.002 |
| Platelet mass |
2,105.76 ± 450.22 |
2,096.83 ± 462.37 |
0.99 (0.91, 1.07) |
0.85 |
| Platelet count [nl] | 243.61 ± 57.72 | 245.11 ± 57.46 | 1.04 (0.97, 1.12) | 0.26 |
The estimates are shown as the adjusted odds ratio with 95% confidence interval (CI) for every unit increase of HbA1c. Model was adjusted for age, sex, waist-hip ratio, blood pressure (diastolic and systolic), cholesterol (total, HDL, LDL), smoking status (categorized: non-smoker, former smoker, current smoker), alcohol intake categorized: ≥20 g/day for women; ≥40 g/day for men), physical activity (categorized: >1 h per week).