Table 4.
Association of mortality with HbA 1c and platelet morphology in non-diabetic participants according to PLA1A2 polymorphism
| |
HbA
1c
≤5.5% |
5.5% < HbA
1c
< 6.5% |
|
|||||
|---|---|---|---|---|---|---|---|---|
|
(HbA
1c
≤37 mmol/mol) |
(37 mmol/mol < HbA
1c
< 48 mmol/mol) |
|||||||
| |
A1A1(N = 1,597) |
|
AxA2(N = 595) |
|
A1A1(N = 1,167) |
|
AxA2(N = 460) |
|
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| HbA1c |
0.81 (0.23, 2.82) |
0.74 |
0.52 (0.08, 3.31) |
0.49 |
1.49 (0.50, 4.49) |
0.48 |
7.85 (1.66, 37.14) |
0.009 |
| Platelet count |
1.04 (1.00, 1.07) |
0.03 |
1.02 (0.94, 1.10) |
0.69 |
0.98 (0.95, 1.02) |
0.35 |
1.01 (0.95, 1.08) |
0.65 |
| Platelet mass |
0.996 (0.992, 0.999) |
0.03 |
1.00 (0.94, 1.10) |
0.66 |
1.00 (0.997, 1.005) |
0.60 |
1.00 (0.991, 1.004) |
0.52 |
| MPV | 2.46 (1.07, 5.61) | 0.03 | 1.34 (0.18, 9.81) | 0.77 | 0.78 (0.33, 1.85) | 0.58 | 1.85 (0.44, 7.76) | 0.40 |
The estimate indicates the hazard ratio (HR) with 95% confidence interval (CI) for every unit increase of the variable. The model was adjusted for age, sex, waist-hip ratio, blood pressure (diastolic and systolic), cholesterol (total, HDL, LDL), smoking status (categorized: non-smoker, former smoker, current smoker), alcohol intake (categorized: ≥20 g/day for women; ≥40 g/day for men), physical activity (categorized: >1 h per week).