Table 5.
Multivariate adjusted hazards ratio of mortality according to different categories of HbA 1c level in people with different genotypes
| |
RR (95% CI) |
|
|---|---|---|
| Categories of HbA1c level | Genotype: A1A1 | Genotype: AxA2 |
| <5% (<31 mmol/mol) |
0.85 (0.34, 2.09) |
1.68 (0.51, 5.61) |
| 5.1/5.2% (32/33 mmol/mol) |
1.29 (0.66, 2.52) |
0.77 (0.18, 3.27) |
| 5.3% (34 mmol/mol) |
1.03 (0.48, 2.21) |
1.18 (0.31, 4.51) |
| 5.4% (36 mmol/mol) |
0.80 (0.36, 1.78) |
1.34 (0.38, 4.72) |
| 5.5% (37 mmol/mol) |
1 |
1 |
| 5.6% (38 mmol/mol) |
0.85 (0.42, 1.72) |
0.51 (0.12, 2.18) |
| 5.7% (39 mmol/mol) |
1.23 (0.64, 2.39) |
1.31 (0.43, 3.99) |
| 5.8% (40 mmol/mol) |
0.69 (0.29, 1.64) |
1.62 (0.46, 5.69) |
| 5.9/6.0% (41/42 mmol/mol) |
0.99 (0.49, 1.99) |
1.37 (0.44, 4.28) |
| >6.5% (>48 mmol/mol) | 1.35 (0.73, 2.51) | 2.97 (1.07, 8.24) |
The hazard ratios and 95% confidence interval are given for each decile of HbA1c level (≤5% (31 mmol/mol), 5.1% (32 mmol/mol)/5.2% (33 mmol/mol), 5.3% (34 mmol/mol), 5.4% (36 mmol/mol), 5.5% (37 mmol/mol), 5.6% (38 mmol/mol), 5.7% (39 mmol/mol), 5.8% (40 mmol/mol), 5.9% (41 mmol/mol)/6.0% (42 mmol/mol), >6.5% (48 mmol/mol)), taking HbA1c = 5.5% (37 mmol/mol) as the reference. The model was adjusted for blood pressure (diastolic and systolic), cholesterol (total, HDL, LDL), smoking status (categorized: non-smoker, former smoker, current smoker), alcohol intake (categorized: ≥20 g/day for women; ≥40 g/day for men), physical activity (categorized: >1 h per week), platelet mass, mean plate volume and platelet count.