Figure 6.

Tidal volume (V_T), frequency, minute ventilation (${\stackrel{.}{V}}_{\mathrm{E}}$) and mean inspiratory flow (V_T/T_I) during baseline and HX + HC in wild-type (WT; black bars) and mutant (MT; white bars) rats treated with apocynin (Apo) + MSX-3 + methy versus sham treated rats. In all groups, HX + HC values were significantly larger than baseline values. Apo + MSX-3 + methy significantly increased V_T, ${\stackrel{.}{V}}_{\mathrm{E}}$ and V_T/T_I during HX + HC in MT rats versus sham treated MT rats. Values are means ± 1 SEM and * = from sham MT, + = from sham WT, where all p < 0.05.