Table 1.
Summary of tidal volume (VT; mL ± SEM) data in baseline, hypoxia (HX), hypercapnia (HC) and hypoxia + hypercapnia (HX + HC) in all treatment groups. Groups were: Sham (WT: n=8; MT: n=9), PCPA (WT: n=3; MT: n=3), PCPA + Methy (WT: n=3; MT: n=3), MSX-3 (WT: n=3; MT: n=3), PCPA + MSX-3 (WT: n=3; MT: n=3), and Apo + MSX-3 + Methy (WT: n=3; MT: n=3). Significance was accepted at p < 0.05; 3 = Sham MT vs. treatment group MT..
| Tidal Volume | Baseline | HX | HC | HX + HC |
|---|---|---|---|---|
| Sham WT | 3.0 ±0.3 | 3.5 ±0.4 | 4.8 ±0.6 | 5.8 ±0.6 |
| Sham MT | 3.4 ±0.2 | 3.9 ±0.3 | 4.9 ±0.3 | 5.3 ±0.4 |
| PCPA WT | 3.8 ± 0.8 | 3.8 ± 0.5 | 5.1 ± 0.6 | 5.8 ± 1.1 |
| PCPA MT | 3.32 ± 0.04 | 3.7 ± 0.2 | 5.2 ± 0.4 | 5.8 ± 0.7 |
| PCPA + Methy WT | 4.3 ± 0.3 | 4.1 ± 0.3 | 7.0 ± 0.4 | 7.1 ± 0.4 |
| PCPA + Methy MT | 3.9 ± 0.2 | 3.8 ± 0.3 | 6.6 ± 0.1 | 7.0 ± 0.1 |
| MSX-3 WT | 3.4 ± 0.1 | 3.5 ± 0.2 | 4.9 ± 0.2 | 5.4 ± 0.1 |
| MSX-3 MT | 3.8 ± 0.2 | 3.9 ± 0.1 | 4.9 ± 0.2 | 5.51 ± 0.04 |
| MSX-3 + PCPA WT | 4.2 ± 0.1 | 4.3 ± 0.2 | 6.3 ± 0.2 | 7.0 ± 0.3 |
| MSX-3 + PCPA MT | 4.5 ± 0.2 | 4.1 ± 0.2 | 6.1 ± 0.1 | 6.9 ± 0.2 |
| Apocynin + MSX-3 + Methy WT | 4.1 ± 0.2 | 4.4 ± 0.1 | 6.3 ± 0.3 | 7.2 ± 0.7 |
| Apocynin + MSX-3 + Methy MT | 4.1 ± 0.3 | 4.4 ± 0.3 | 6.7 ± 0.4 | 7.6 ± 0.53 |