Figure 8. Gaussian noise added to PRC cannot mimic both the hybrid circuit data and the noise level in the PRC with the same parameter value.
A. Simulation of hybrid network for Experiment 19 illustrated in Figure 7A1. (A1) Low noise case does not capture network dynamics. (A2) High noise case better reproduces network dynamics. (B). Comparison of experimental (red dots) and representative simulated (blue dots) PRC measurements. The experimentally measured PRC from the biological cell in experiment 19 is fitted with a 3rd degree polynomial (black curve). (B1) The low noise case captures the variability in the PRC quite well. (B2) The high noise case vastly overestimates variability in PRC. For low noise σ = 0.0014 and for high noise σ = 0.0344.