Table 1. Blood parameters.

Genotype	SHHF+/?	SHHFcp/cp	SHHF+/?	SHHFcp/cp		ANOVA
Parameters
Age, month	1.5	1.5	14	14	Genotype	Age	Interaction
N	7–12	5–10	7	5
Ionogram, mmol/l
Na+	140.8±0.5	141.4±0.6	143.7±0.7§§§	143.0±0.8	ns	0.0003	ns
K+	4.8±0.2	4.9±0.2	5.3±0.2	4.7±0.2	ns	ns	ns
Na+/K+ ratio	29.8±0.9	28.8±1.0	28.1±1.2	30.3±1.4	ns	ns	ns
Lipidic profil, g/l
Total Cholesterol	0.7±0.2	0.9±0.3***	0.8±0.3	4.6±0.4***§§§	<0.0001	<0.0001	<0.0001
HDL	0.2±0.0	0.3±0.0**	0.2±0.0	0.4±0.0***§§§	<0.0001	<0.0001	<0.0001
LDL	0.4±0.1	0.5±0.1	0.4±0.1	1.3±0.2§	0.0026	0.0045	0.0141
FFA	1.1±0.4	1.7±0.5*	1.1±0.5	5.2±0.6*§	<0.0001	0.0045	0.0023
TG	0.3±0.7	0.8±0.0*	0.5±0.1	14.6±1.1***§§§	<0.0001	<0.0001	<0.0001
Fasting glycemia, mg/dl	83±5	100±12	107±5	92±9	ns	ns	ns
Fasting insulin, µIU/ml	12±2	25±4	16±4§§	226±92***§§§	0.007	0.004	0.009
HOMA-IR index	0.9±0.3	2.6±0.8***	2.0±0.3§§§	14.6±5.9***§§	0.004	0.007	0.022
Creatinine, mmol/l	2.13±0.60	1.88±0.69**	4.60±0.79§§§	8.00±0.93***§§§	0.0489	<0.0001	0.0244
BNP, pg/ml	117±18	116±24	212±29§§	207±29§§	ns	0.0013	ns
Adiponectin, µg/ml	6.4±0.5	19.7±0.8***	5.3±0.7§	12.8±0.8***§§§	<0.0001	<0.0001	0.0007

Na⁺, sodium, K⁺, potassium; HDL, High Density Lipoprotein; LDL, Low density Lipoprotein; FFA, Free Fatty Acids; TG, triglyceride; BNP, Brain Natriuretic Peptide. Values are the mean±sem. Non-parametric ANOVAs analysis with two factors allowed the evaluation of interaction between aging and genotype. Student's T test * p<0.05; ** p<0.01, *** p<0.001 to compare SHHF ^cp/cp vs. SHHF^+/? at same time point; § p<0.05; §§p<0.01, §§§ p<0.001 to compare T14-mo vs T1.5-mo for a same genotype; N stands for the number of samples; ns stands for not significant.