Table 3.
Univariate and multivariate Cox regression analyses GAS5 for DFS or OS of patients in study cohort (n = 89)
|
Variables |
DFS |
OS |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
|
Univariate analysis |
|
|
|
|
. |
|
| Age (<50 years vs. >50 years) |
1.122 |
0.659-1.910 |
0.671 |
1.057 |
0.589-1.899 |
0.852 |
| Gender (male vs. female) |
1.584 |
0.907-2.768 |
0.106 |
1.739 |
0.933-3.240 |
0.082 |
| Location (Distal vs. Middle + Proximal) |
1.232 |
0.811-1.872 |
0.327 |
1.498 |
0.830-2.702 |
0.180 |
| tumor size (>5 cm vs. <5 cm) |
1.493 |
0.876-2.543 |
0.141 |
1.260 |
0.938-1.692 |
0.124 |
| Histologic differentiation (Well + Moderately vs. Poorly + Undifferentiated) |
0.743 |
0.428-1.288 |
0.289 |
0.798 |
0.436-1.458 |
0.463 |
| Invasion depth (T1 + T2 vs.T3 + T4) |
0.629 |
0.370-1.069 |
0.087 |
0.724 |
0.403-1.300 |
0.279 |
| TNM stage (I + II vs. III + IV) |
0.521 |
0.303-0.896 |
0.018** |
0.433 |
0.239-0.786 |
0.006** |
| Lymphatic metastasis (No vs. Yes) |
0.838 |
0.642-1.093 |
0.192 |
0.899 |
0.671-1.204 |
0.474 |
| Regional lymph nodes (PN0+ PN1vs. PN2+ PN3) |
0.584 |
0.332-1.024 |
0.061 |
0.575 |
0.310-1.065 |
0.078 |
| Distant metastasis (No vs. Yes) |
0.456 |
0.264-0.787 |
0.005** |
0.432 |
0.231-0.811 |
0.009** |
| Expression of GAS5 (High vs. Low) |
0.407 |
0.235-0.706 |
0.001** |
0.591 |
0.436-0.803 |
0.001** |
|
Multivariate analysis |
|
|
|
|
|
|
| TNM stage (I + II vs. III + IV) |
0.631 |
0.357-1.115 |
0.113 |
0.537 |
0.289-1.000 |
0.049* |
| Distant metastasis (No vs. Yes) |
0.384 |
0.123-1.197 |
0.099 |
0.381 |
0.105-1.389 |
0.144 |
| Expression of GAS5 (High vs. Low) | 0.466 | 0.263-0.828 | 0.009** | 0.412 | 0.218-0.776 | 0.006** |
DFS, disease-free survival; OS, overall survival; HR, hazard ratio; 95% CI, 95% confidence interval. *P < 0.05 and **P < 0.01.