Figure 4. Tumour growth and survival following anti-CD25 Ab.

(a) There was no significant difference between tumour growth rates between mice fed tumour (temporarily or permanently) and control mice. Mice which received no anti-CD25 Ab depletion showed significantly different tumour growth rates at days 14, 18 and 22 depending on whether they had been fed tumour and saline (p<0.05). Each data point represents mean tumour values for 10 mice. (b) Survival curve for mice that were permanently, temporarily or not depleted during the induction of oral tolerance. Mice that were permanently depleted were 100% cured of their subcutaneous tumour and remained disease free at 100 days. 75% of those that were temporarily depleted while fed tumour were cured, while 66% of those that were temporarily depleted and fed PBS cured. There was no significant difference between these groups. All of those mice that received isotype control Ab succumbed to tumour burden (n = 10).