Figure 1. Extension of yeast chronological lifespan (CLS) by methionine restriction (Meth-R).

(A) Effects of methionine biosynthetic deficiencies (genetic Meth-R) on CLS, (B) Effect of dietary Meth-R on CLS, (C) Effect of pH-buffering (BUF) on CLS, (D) Survival of wild-type and met15Δ cells following treatment with increasing amounts of acetic acid, (E) Requirement of the retrograde response for CLS extension by genetic Meth-R. For all panels, bars denote standard error of the mean (SEM).